Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering

Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering

Objective: Skeletal muscle is an attractive target for blood glucose-lowering pharmacological interventions. Oral dosing of small molecule direct pan-activators of AMPK that bind to the allosteric drug and metabolite (ADaM) site, lowers blood glucose through effects in skeletal muscle. The molecular...

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Bibliographic Details
Main Authors: Nicolas O. Jørgensen, Rasmus Kjøbsted, Magnus R. Larsen, Jesper B. Birk, Nicoline R. Andersen, Bina Albuquerque, Peter Schjerling, Russell Miller, David Carling, Christian K. Pehmøller, Jørgen F.P. Wojtaszewski
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Metabolism
Subjects:
AMP-activated protein kinase
Skeletal muscle
Glucose uptake
Metabolism
Metabolic disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001046

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http://www.sciencedirect.com/science/article/pii/S2212877821001046

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