Regional White Matter Integrity Predicts Treatment Response to Escitalopram and Memantine in Geriatric Depression: A Pilot Study

Regional White Matter Integrity Predicts Treatment Response to Escitalopram and Memantine in Geriatric Depression: A Pilot Study

Background: Geriatric depression with subjective memory complaints increases the risk for Alzheimer's Disease. Memantine, a neuroprotective drug, can improve depression and help prevent cognitive decline. In our 6-months clinical trial, escitalopram/memantine (ESC/MEM) improved mood and cogniti...

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Bibliographic Details
Main Authors: Beatrix Krause-Sorio, Prabha Siddarth, Michaela M. Milillo, Roza Vlasova, Linda Ercoli, Katherine L. Narr, Helen Lavretsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Psychiatry
Subjects:
geriatric depression
cognitive decline
memantine
magnetic resonance imaging
diffusion weighted imaging
white matter integrity
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2020.548904/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2020.548904/full

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