Cerebrolysin Ameliorates Focal Cerebral Ischemia Injury Through Neuroinflammatory Inhibition via CREB/PGC-1α Pathway

Cerebrolysin Ameliorates Focal Cerebral Ischemia Injury Through Neuroinflammatory Inhibition via CREB/PGC-1α Pathway

Neuroinflammation is one of the important factors aggravating brain injury after ischemic stroke. We aimed to investigate the effects of cerebrolysin (CBL) on neuroinflammation in vivo and in vitro and the underlying mechanisms. The gene expressions of pro-inflammatory factors and anti-inflammatory...

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Bibliographic Details
Main Authors: Xin Guan, Yunjie Wang, Guoyin Kai, Shunyi Zhao, Tingyu Huang, Youzhen Li, Yuan Xu, Luyong Zhang, Tao Pang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
cerebrolysin
ischemic stroke
microglia
cAMP response element-binding protein
peroxisome proliferator-activated receptor gamma co-activator 1α
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01245/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01245/full

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