Systems Biology Guided Gene Enrichment Approaches Improve Prediction of Chronic Post-surgical Pain After Spine Fusion

Systems Biology Guided Gene Enrichment Approaches Improve Prediction of Chronic Post-surgical Pain After Spine Fusion

ObjectivesIncorporation of genetic factors in psychosocial/perioperative models for predicting chronic postsurgical pain (CPSP) is key for personalization of analgesia. However, single variant associations with CPSP have small effect sizes, making polygenic risk assessment important. Unfortunately,...

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Bibliographic Details
Main Authors: Vidya Chidambaran, Valentina Pilipenko, Anil G. Jegga, Kristie Geisler, Lisa J. Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
systems biology
genetics
polygenic risk score
chronic post-surgical pain
gene enrichment
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.594250/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.594250/full

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