The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro

The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro

In the present study, we investigated the role of the main intracellular energy sensor, AMP-activated protein kinase (AMPK), in the in vitro neurotoxicity of α-synuclein (ASYN), one of the key culprits in the pathogenesis of Parkinson's disease. The loss of viability in retinoic acid-differenti...

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Bibliographic Details
Main Authors: Marija Dulovic, Maja Jovanovic, Maria Xilouri, Leonidas Stefanis, Ljubica Harhaji-Trajkovic, Tamara Kravic-Stevovic, Verica Paunovic, Mustafa T. Ardah, Omar M.A. El-Agnaf, Vladimir Kostic, Ivanka Markovic, Vladimir Trajkovic
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Neurobiology of Disease
Subjects:
Alpha-synuclein
Neurotoxicity
Neuroprotection
AMPK
Akt
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113003148

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http://www.sciencedirect.com/science/article/pii/S0969996113003148

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