In-Silico Characterization and in-Vivo Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease

In-Silico Characterization and in-Vivo Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia, excessive acetylcholinesterase (AChE) activity, formation of neurotoxic amyloid plaque, and tau protein aggregation. Based on literature survey, we have shortlisted three important target proteins (AChE, COX2, a...

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Bibliographic Details
Main Authors: Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul-Ain, Tassadaq H. Jafar, Rabia Rasool, Aasia Kalsoom, Muhammad A. Ghafoor, Sheikh A. Sehgal, Kalamegam Gauthaman, Muhammad I. Naseer, Mohammed H. Al-Qahtani, Peter N. Pushparaj
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer's disease
acetylcholinesterase (AChE)
salvadorin
Albiziasaponin A
iso-orientin
in silico modeling
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00730/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00730/full

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