Sex Metabolic Differences and Effects on Blood Coagulation Among Rats Exposed to Sodium Dehydroacetate

Sex Metabolic Differences and Effects on Blood Coagulation Among Rats Exposed to Sodium Dehydroacetate

Sodium dehydroacetate (Na-DHA), a fungicide used in food, feed, cosmetics, and medicine, has been found to cause coagulation aberration accompanied by the inhibition of vitamin K epoxide reductase (VKOR) in the liver in rats. VKOR complex 1 (VKORC1) and VKORC1 like-1 (VKORC1L1) are two homologous VK...

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Bibliographic Details
Main Authors: Xin Chen, Fuxing Hao, Meng Zhang, Jinzha Xiao, Weiya Zhao, Zeting Zhao, Yumei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
sodium dehydroacetate
metabolism
blood coagulation
cytochrome P450
VKORC1L1
sex difference
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.727084/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.727084/full

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