Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma

Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma

Abstract Background The prognosis of synovial sarcoma (SS), an aggressive soft tissue sarcoma, remains poor. We previously reported that c-MET or platelet-derived growth factor receptor α (PDGFRα) signalling pathway is related to SS progression based upon the findings of phospho-receptor tyrosine ki...

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Bibliographic Details
Main Authors: Shutaro Yamada, Yoshinori Imura, Takaaki Nakai, Sho Nakai, Naohiro Yasuda, Keiko Kaneko, Hidetatsu Outani, Satoshi Takenaka, Kenichiro Hamada, Akira Myoui, Nobuhito Araki, Takafumi Ueda, Kazuyuki Itoh, Hideki Yoshikawa, Norifumi Naka
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Cancer
Subjects:
TAS-115
Synovial sarcoma
C-MET
PDGFRα
Molecular targeted therapy
Online Access:http://link.springer.com/article/10.1186/s12885-017-3324-3

Internet

http://link.springer.com/article/10.1186/s12885-017-3324-3

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