Thrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells

Thrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells

Abstract Background Cancer-associated fibroblasts (CAFs), the primary component of tumor stroma in tumor microenvironments, are well-known contributors to the malignant progression of gallbladder cancer (GBC). Thrombospondins (THBSs or TSPs) comprise a family of five adhesive glycoproteins that are...

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Bibliographic Details
Main Authors: Yu Shi, Liankang Sun, Rui Zhang, Yuan Hu, Yinying Wu, Xuyuan Dong, Danfeng Dong, Chen Chen, Zhimin Geng, Enxiao Li, Yangwei Fan
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gallbladder cancer
Cancer-associated fibroblasts
Thrombospondin 4
Heat shock factor 1
Proliferation
Cancer stemness
Online Access:https://doi.org/10.1186/s13046-020-01812-7

Internet

https://doi.org/10.1186/s13046-020-01812-7

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