Thrombospondin 4/integrin α2/HSF1 axis promotes proliferation and cancer stem-like traits of gallbladder cancer by enhancing reciprocal crosstalk between cancer-associated fibroblasts and tumor cells
Abstract Background Cancer-associated fibroblasts (CAFs), the primary component of tumor stroma in tumor microenvironments, are well-known contributors to the malignant progression of gallbladder cancer (GBC). Thrombospondins (THBSs or TSPs) comprise a family of five adhesive glycoproteins that are...
Main Authors: | Yu Shi, Liankang Sun, Rui Zhang, Yuan Hu, Yinying Wu, Xuyuan Dong, Danfeng Dong, Chen Chen, Zhimin Geng, Enxiao Li, Yangwei Fan |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-01-01
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Series: | Journal of Experimental & Clinical Cancer Research |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13046-020-01812-7 |
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