Hypercapnia Impairs Na,K-ATPase Function by Inducing Endoplasmic Reticulum Retention of the β-Subunit of the Enzyme in Alveolar Epithelial Cells

Hypercapnia Impairs Na,K-ATPase Function by Inducing Endoplasmic Reticulum Retention of the β-Subunit of the Enzyme in Alveolar Epithelial Cells

Alveolar edema, impaired alveolar fluid clearance, and elevated CO<sub>2</sub> levels (hypercapnia) are hallmarks of the acute respiratory distress syndrome (ARDS). This study investigated how hypercapnia affects maturation of the Na,K-ATPase (NKA), a key membrane transporter, and a cell...

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Bibliographic Details
Main Authors: Vitalii Kryvenko, Miriam Wessendorf, Rory E. Morty, Susanne Herold, Werner Seeger, Olga Vagin, Laura A. Dada, Jacob I. Sznajder, István Vadász
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
carbon dioxide
hypercapnia
na,k-atpase
endoplasmic reticulum
sodium transport
protein oxidation
alveolar epithelium
Online Access:https://www.mdpi.com/1422-0067/21/4/1467

Internet

https://www.mdpi.com/1422-0067/21/4/1467

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