Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway

Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway

Tryptophan 2,3-dioxygnease 2 (TDO2) is specific for metabolizing tryptophan to kynurenine (KYN), which plays a critical role in mediating immune escape of cancer. Although accumulating evidence demonstrates that TDO2 overexpression is implicated in the development and progression of multiple cancers...

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Bibliographic Details
Main Authors: Yumiao Zhao, Jiaxin Sun, Yin Li, Xiuman Zhou, Wenjie Zhai, Yahong Wu, Guanyu Chen, Shanshan Gou, Xinghua Sui, Wenshan Zhao, Lu Qiu, Yongjie Yao, Yixuan Sun, Chunxia Chen, Yuanming Qi, Yanfeng Gao
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Tryptophan 2,3-dioxygenase 2
M2 macrophage
Esophageal squamous cell carcinoma
IL-8
KYN
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521000800

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http://www.sciencedirect.com/science/article/pii/S2211383521000800

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