ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation

ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation

ApoA-I, the main protein component of HDL, is suggested to be involved in metabolic homeostasis. We examined the effects of Milano, a naturally occurring ApoA-I variant, about which little mechanistic information is available. Remarkably, high-fat-fed mice treated with Milano displayed a rapid weigh...

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Bibliographic Details
Main Authors: Maria Lindahl, Jitka Petrlova, Jonathan Dalla-Riva, Sebastian Wasserstrom, Catarina Rippe, Joan Domingo-Espin, Dorota Kotowska, Ewa Krupinska, Christine Berggreen, Helena A. Jones, Karl Swärd, Jens O. Lagerstedt, Olga Göransson, Karin G. Stenkula
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Journal of Lipid Research
Subjects:
adipose tissue
apolipoprotein A-I
cholesterol
diabetes
obesity
adenosine 3′,5′-cyclic monophosphate
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309457

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http://www.sciencedirect.com/science/article/pii/S0022227520309457

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