Motor Sequence Learning Deficits in Idiopathic Parkinson’s Disease Are Associated With Increased Substantia Nigra Activity

Motor Sequence Learning Deficits in Idiopathic Parkinson’s Disease Are Associated With Increased Substantia Nigra Activity

Previous studies have shown that persons with Parkinson’s disease (pwPD) share specific deficits in learning new sequential movements, but the neural substrates of this impairment remain unclear. In addition, the degree to which striatal dopaminergic denervation in PD affects the cortico-striato-tha...

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Bibliographic Details
Main Authors: Elinor Tzvi, Richard Bey, Matthias Nitschke, Norbert Brüggemann, Joseph Classen, Thomas F. Münte, Ulrike M. Krämer, Jost-Julian Rumpf
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
motor sequence learning
fMRI
dynamic causal modeling
substantia nigra
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.685168/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.685168/full

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