AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation

AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation

Advanced glycation end products (AGEs) are localized in macrophage-derived foam cells within atherosclerotic lesions, which could be associated with the increased risk of atherosclerotic cardiovascular disease under diabetic conditions. Although foam cell formation of macrophages has been shown to b...

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Bibliographic Details
Main Authors: Hironori Yashima, Michishige Terasaki, Ami Sotokawauchi, Takanori Matsui, Yusaku Mori, Tomomi Saito, Naoya Osaka, Hideki Kushima, Munenori Hiromura, Makoto Ohara, Tomoyasu Fukui, Sho-ichi Yamagishi
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
AGEs
Cdk5
CD36
RAGE-aptamer
macrophages
Online Access:https://www.mdpi.com/1422-0067/21/23/9263

Internet

https://www.mdpi.com/1422-0067/21/23/9263

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