The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential

The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential

Cancer stem cells (CSC) are responsible for cancer chemoresistance and metastasis formation. Here we report that Δ133p53β, a TP53 splice variant, enhanced cancer cell stemness in MCF-7 breast cancer cells, while its depletion reduced it. Δ133p53β stimulated the expression of the key pluripotency fac...

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Bibliographic Details
Main Authors: Nikola Arsic, Gilles Gadea, E. Louise Lagerqvist, Muriel Busson, Nathalie Cahuzac, Carsten Brock, Frederic Hollande, Veronique Gire, Julie Pannequin, Pierre Roux
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115000430

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http://www.sciencedirect.com/science/article/pii/S2213671115000430

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