On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.

On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.

For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, it maintains the same robustness against population admixture as traditiona...

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Bibliographic Details
Main Authors: Sungho Won, Jemma B Wilk, Rasika A Mathias, Christopher J O'Donnell, Edwin K Silverman, Kathleen Barnes, George T O'Connor, Scott T Weiss, Christoph Lange
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2777973?pdf=render

Internet

http://europepmc.org/articles/PMC2777973?pdf=render

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