Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.

CDH11 gene copy number and expression are frequently lost in human retinoblastomas and in retinoblastomas arising in TAg-RB mice. To determine the effect of Cdh11 loss in tumorigenesis, we crossed Cdh11 null mice with TAg-RB mice. Loss of Cdh11 had no gross morphological effect on the developing ret...

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Bibliographic Details
Main Authors: Mellone N Marchong, Christine Yurkowski, Clement Ma, Clarellen Spencer, Sanja Pajovic, Brenda L Gallie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2858707?pdf=render