CXCL12 MODULATION OF CXCR4 AND CXCR7 ACTIVITY IN HUMAN GLIOBLASTOMA STEM-LIKE CELLS AND REGULATION OF THE TUMOR MICROENVIRONMENT

CXCL12 MODULATION OF CXCR4 AND CXCR7 ACTIVITY IN HUMAN GLIOBLASTOMA STEM-LIKE CELLS AND REGULATION OF THE TUMOR MICROENVIRONMENT

Chemokines are crucial autocrine and paracrine players in tumor development. In particular, CXCL12, through its receptors CXCR4 and CXCR7, affects tumor progression by controlling cancer cell survival, proliferation and migration, and, indirectly, via angiogenesis or recruiting immune cells.<br/&...

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Bibliographic Details
Main Authors: Roberto eWurth, Adriana eBajetto, Jeffrey K. Harrison, Federica eBarbieri, Tullio eFlorio
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Glioblastoma
CXCR4
cancer stem cells
CXCL12
CXCR7
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00144/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00144/full

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