Inflammation and insulin resistance induced by trans-10, cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes

Inflammation and insulin resistance induced by trans-10, cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes

We previously demonstrated that trans-10, cis-12 (10,12) conjugated linoleic acid (CLA) induced inflammation and insulin resistance in primary human adipocytes by activating nuclear factor κB (NFκB) and extracellular signal-related kinase (ERK) signaling. In this study, we demonstrated that the init...

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Bibliographic Details
Main Authors: Arion Kennedy, Kristina Martinez, Soonkyu Chung, Kathy LaPoint, Robin Hopkins, Soren F. Schmidt, Kenneth Andersen, Susanne Mandrup, Michael McIntosh
Format: Article
Language:English
Published: Elsevier 2010-07-01
Series:Journal of Lipid Research
Subjects:
cell signaling
fatty acid
reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520371133

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http://www.sciencedirect.com/science/article/pii/S0022227520371133

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