Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells

Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells

Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem cell compartment integrity. Normal adult stem cells have the longest telomeres in a given tissue, a property mediated by high hTERT expression and high telomerase enzymatic activity. In contrast, cance...

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Bibliographic Details
Main Authors: Ahmed El-Badawy, Nehal I. Ghoneim, Mohamed A. Nasr, Hoda Elkhenany, Toka A. Ahmed, Sara M. Ahmed, Nagwa El-Badri
Format: Article
Language:English
Published: The Company of Biologists 2018-07-01
Series:Biology Open
Subjects:
HTERT
CSCs
Cancer metastasis
Chemoresistance
Online Access:http://bio.biologists.org/content/7/7/bio034181

Internet

http://bio.biologists.org/content/7/7/bio034181

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