Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis

Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis

Invasive aspergillosis (IA) is a life-threatening infection due to Aspergillus fumigatus and other Aspergillus spp. Drugs targeting the fungal cell membrane (triazoles, amphotericin B) or cell wall (echinocandins) are currently the sole therapeutic options against IA. Their limited efficacy and the...

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Bibliographic Details
Main Authors: Frederic eLamoth, Praveen Rao Juvvadi, William J Steinbach
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Microbiology
Subjects:
Aspergillus fumigatus
antifungal resistance
Trichostatin A
antifungal therapy
Heat shock protein 90 (hsp90)
Lysine deacetylases
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00096/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00096/full

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