Reconstructing high-resolution chromosome three-dimensional structures by Hi-C complex networks

Reconstructing high-resolution chromosome three-dimensional structures by Hi-C complex networks

Abstract Background Hi-C data have been widely used to reconstruct chromosomal three-dimensional (3D) structures. One of the key limitations of Hi-C is the unclear relationship between spatial distance and the number of Hi-C contacts. Many methods used a fixed parameter when converting the number of...

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Bibliographic Details
Main Authors: Tong Liu, Zheng Wang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Bioinformatics
Subjects:
Chromosomal three-dimensional structure
Hi-C complex network
Wish distance
Converting parameter
Small-world network
Topologically associating domain
Online Access:http://link.springer.com/article/10.1186/s12859-018-2464-z

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http://link.springer.com/article/10.1186/s12859-018-2464-z

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