Association of uPA and PAI-1 tumor levels and 4G/5G variants of PAI-1 gene with disease outcome in luminal HER2-negative node-negative breast cancer patients treated with adjuvant endocrine therapy

Association of uPA and PAI-1 tumor levels and 4G/5G variants of PAI-1 gene with disease outcome in luminal HER2-negative node-negative breast cancer patients treated with adjuvant endocrine therapy

Abstract Background The aim of this study was to evaluate the prognostic potential of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) tumor tissue levels and examine the association between these biomarkers and classical prognostic factors in early node-...

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Bibliographic Details
Main Authors: Marko Jevrić, Ivana Z. Matić, Ana Krivokuća, Marija Đorđić Crnogorac, Irina Besu, Ana Damjanović, Mirjana Branković-Magić, Zorka Milovanović, Dušica Gavrilović, Snezana Susnjar, Darija Kisić Tepavčević, Tatjana Stanojković
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Cancer
Subjects:
uPA
PAI-1
PAI-1 –675 4G/5G polymorphism
Prognostic
Luminal/HER2-negative, node-negative breast cancer
Adjuvant endocrine therapy
Online Access:http://link.springer.com/article/10.1186/s12885-018-5255-z

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http://link.springer.com/article/10.1186/s12885-018-5255-z

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