Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events

Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events

Abstract Background Laboratory assays evaluating the effect of DNA sequence variants on BRCA1 mRNA splicing may contribute to classification by providing molecular evidence. However, our knowledge of normal and aberrant BRCA1 splicing events to date has been limited to data derived from assays targe...

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Bibliographic Details
Main Authors: Lucy C. de Jong, Simone Cree, Vanessa Lattimore, George A. R. Wiggins, Amanda B. Spurdle, kConFab Investigators, Allison Miller, Martin A. Kennedy, Logan C. Walker
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Breast Cancer Research
Subjects:
BRCA1
Splicing
MinION
Nanopore sequencing
Full-length transcript
Exon skipping
Online Access:http://link.springer.com/article/10.1186/s13058-017-0919-1

Internet

http://link.springer.com/article/10.1186/s13058-017-0919-1

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