Nucleostemin depletion induces post-G1 arrest apoptosis in chronic myelogenous leukemia K562 cells

Nucleostemin depletion induces post-G1 arrest apoptosis in chronic myelogenous leukemia K562 cells

Abstract Purpose: Despite significant improvements in treatment of chronic myelogenous leukemia (CML), the emergence of leukemic stem cell (LSC) concept questioned efficacy of current therapeutical protocols. Remaining issue on CML includes finding and targeting of the key genes responsible for se...

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Bibliographic Details
Main Authors: Negin Gogani, Marveh Rahmati, Nosratollah Zarghami, Iraj Asvadi-Kermani, Mohammad Ali Hoseinpour-Feyzi, Mohammad Amin Moosavi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2014-03-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Apoptosis
Cell cycle
Nucleostemin
K562
RNA interference
Online Access:http://journals.tbzmed.ac.ir/APB/Manuscript/APB-4-55.pdf

Internet

http://journals.tbzmed.ac.ir/APB/Manuscript/APB-4-55.pdf

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