Immunogenomic pathways associated with cytotoxic lymphocyte infiltration and survival in colorectal cancer

Abstract Background Colorectal cancer (CRC) is the second leading cancer killer in the US today and patients with metastatic disease have only a 14% 5-year survival. One of the most impactful recent advances in cancer therapy, immune checkpoint inhibition, has not been shown to be effective for the...

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Bibliographic Details
Main Authors: Yuanyuan Shen, Yue Guan, Justin J. Hummel, Chi-Ren Shyu, Jonathan B. Mitchem
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12885-020-6513-4