ΗΙF1α, EGR1 and SP1 co-regulate the erythropoietin receptor expression under hypoxia: an essential role in the growth of non-small cell lung cancer cells

ΗΙF1α, EGR1 and SP1 co-regulate the erythropoietin receptor expression under hypoxia: an essential role in the growth of non-small cell lung cancer cells

Abstract Background Overexpression of erythropoietin (EPO) and EPO receptor (EPO-R) is associated with poor prognosis in non-small-cell lung carcinoma (NSCLC). Hypoxia, a potent EPO inducer, is a major stimulating factor in the growth of solid tumors. However, how EPO-R expression is regulated under...

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Bibliographic Details
Main Authors: Tianhong Su, Pi Liu, Xinyu Ti, Shouzhen Wu, Xiaochang Xue, Zenglu Wang, Elhardji Dioum, Qiuyang Zhang
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cell Communication and Signaling
Subjects:
NSCLC
Hypoxia
EPO-R
Online Access:http://link.springer.com/article/10.1186/s12964-019-0458-8

Internet

http://link.springer.com/article/10.1186/s12964-019-0458-8

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