FoxO1 gain of function in the pancreas causes glucose intolerance, polycystic pancreas, and islet hypervascularization.

FoxO1 gain of function in the pancreas causes glucose intolerance, polycystic pancreas, and islet hypervascularization.

Genetic studies revealed that the ablation of insulin/IGF-1 signaling in the pancreas causes diabetes. FoxO1 is a downstream transcription factor of insulin/IGF-1 signaling. We previously reported that FoxO1 haploinsufficiency restored β cell mass and rescued diabetes in IRS2 knockout mice. However,...

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Bibliographic Details
Main Authors: Osamu Kikuchi, Masaki Kobayashi, Kosuke Amano, Tsutomu Sasaki, Tomoya Kitazumi, Hye-Jin Kim, Yong-Soo Lee, Hiromi Yokota-Hashimoto, Yukari-Ido Kitamura, Tadahiro Kitamura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3285669?pdf=render

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http://europepmc.org/articles/PMC3285669?pdf=render

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