Genetic Variants Related to Cardiometabolic Traits Are Associated to B Cell Function, Insulin Resistance, and Diabetes Among AmeriCan Indians: The Strong Heart Family Study

Genetic Variants Related to Cardiometabolic Traits Are Associated to B Cell Function, Insulin Resistance, and Diabetes Among AmeriCan Indians: The Strong Heart Family Study

Background: Genetic research may inform underlying mechanisms for disparities in the burden of type 2 diabetes mellitus among American Indians. Our objective was to assess the association of genetic variants in cardiometabolic candidate genes with B cell dysfunction via HOMA-B, insulin resistance vi...

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Bibliographic Details
Main Authors: Poojitha Balakrishnan, Dhananjay Vaidya, V. Saroja Voruganti, Karin Haack, Jack W. Kent, Kari E. North, Sandra Laston, Barbara V. Howard, Jason G. Umans, Elisa T. Lee, Lyle G. Best, Jean W. MacCluer, Shelley A. Cole, Ana Navas-Acien, Nora Franceschini
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Genetics
Subjects:
American Indian
insulin-secreting cells
insulin resistance
genome-wide association study
diabetes mellitus
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00466/full

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https://www.frontiersin.org/article/10.3389/fgene.2018.00466/full

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