Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

The transgenic E1-DN mice express a kinase-negative epidermal growth factor receptor in their pancreatic islets and are diabetic from two weeks of age due to impaired postnatal growth of β-cell mass. Here, we characterize the development of hyperglycaemia-induced renal injury in the E1-DN mice. Homo...

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Bibliographic Details
Main Authors: Mervi E. Hyvönen, Vincent Dumont, Jukka Tienari, Eero Lehtonen, Jarkko Ustinov, Marika Havana, Hannu Jalanko, Timo Otonkoski, Päivi J. Miettinen, Sanna Lehtonen
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/102969

Internet

http://dx.doi.org/10.1155/2015/102969

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