Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [Na+]i/[K+]i-Dependent Gene Expression

Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [Na+]i/[K+]i-Dependent Gene Expression

Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na,K-ATPase, the enzyme, which pumps Na+ and K+ across plasma membrane of animal cells. Treatment of cells by CTS affects v...

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Bibliographic Details
Main Authors: Olga Dmitrievna Lopina, Artem Mikhaylovich Tverskoi, Elizaveta Andreevna Klimanova, Svetlana Vadimovna Sidorenko, Sergei Nikolaevich Orlov
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
cardiotonic steroids
ouabain
cell death
Na,K-ATPase
intracellular Na+ and K+
gene expression
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.01060/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.01060/full

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