Palmitoylethanolamide Inhibits Glutamate Release in Rat Cerebrocortical Nerve Terminals

Palmitoylethanolamide Inhibits Glutamate Release in Rat Cerebrocortical Nerve Terminals

The effect of palmitoylethanolamide (PEA), an endogenous fatty acid amide displaying neuroprotective actions, on glutamate release from rat cerebrocortical nerve terminals (synaptosomes) was investigated. PEA inhibited the Ca2+-dependent release of glutamate, which was triggered by exposing synaptos...

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Bibliographic Details
Main Authors: Tzu-Yu Lin, Cheng-Wei Lu, Chia-Chan Wu, Shu-Kuei Huang, Su-Jane Wang
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
PEA
glutamate release
cerebrocortical nerve terminals
voltage-dependent Ca2+ channels
cannabinoid CB1 receptors
protein kinase A
Online Access:http://www.mdpi.com/1422-0067/16/3/5555

Internet

http://www.mdpi.com/1422-0067/16/3/5555

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