Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons

Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons

Abstract Mitochondrial structural changes are associated with the regulation of mitochondrial function, apoptosis, and neurodegenerative diseases. PRKN is known to be involved with various mechanisms of mitochondrial quality control including mitochondrial structural changes. Parkinson’s disease (PD...

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Bibliographic Details
Main Authors: Mutsumi Yokota, Soichiro Kakuta, Takahiro Shiga, Kei-ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Wado Akamatsu, Masato Koike
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Brain
Subjects:
Mitochondria
Ultrastructure
PRKN
IPSC
Dopaminergic neurons
Online Access:https://doi.org/10.1186/s13041-021-00771-0

Internet

https://doi.org/10.1186/s13041-021-00771-0

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