siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids[S]

siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids[S]

Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE–/– and low density lipoprotein receptor (LDLr)–/– mice have been extensively used for studies of coronary atherosclerosis. These animals show atherosclerotic lesions s...

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Bibliographic Details
Main Authors: Marija Tadin-Strapps, Laurence B. Peterson, Anne-Marie Cumiskey, Raymond L. Rosa, Vivienne Halili Mendoza, Jose Castro-Perez, Oscar Puig, Liwen Zhang, Walter R. Strapps, Satyasri Yendluri, Lori Andrews, Victoria Pickering, Julie Rice, Lily Luo, Zhu Chen, Samnang Tep, Brandon Ason, Elizabeth Polizzi Somers, Alan B. Sachs, Steven R. Bartz, Jenny Tian, Jayne Chin, Brian K. Hubbard, Kenny K. Wong, Lyndon J. Mitnaul
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Journal of Lipid Research
Subjects:
low density lipoprotein cholesterol
low density lipoprotein receptor
cholesteryl ester transfer protein
short-interfering RNA
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520313274

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http://www.sciencedirect.com/science/article/pii/S0022227520313274

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