IL-1β but not programmed death-1 and programmed death-ligand pathway is critical for the human Th17 response to M. tuberculosis

IL-1β but not programmed death-1 and programmed death-ligand pathway is critical for the human Th17 response to M. tuberculosis

The programmed death-1 (PD-1)- programmed death ligand-1 (PD-L1) and PD-L2 co-inhibitory pathway has been implicated in the evasion strategies of Mycobacterium tuberculosis. Specifically, M. tuberculosis-induced PD-L1 orchestrates expansion of regulatory T cells (Tregs) and suppression of Th1 respon...

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Bibliographic Details
Main Authors: Emmanuel Stephen-Victor, Varun Kumar Sharma, Mrinmoy Das, Anupama Karnam, chaitrali Saha, Maxime Lecerf, Caroline Galeotti, Srinivas Kaveri, Jagadeesh BAYRY
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Dendritic Cells
Monocytes
Mycobacterium tuberculosis
T cells
IL-23
Th17
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00465/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00465/full

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