Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

Tyrosine kinase inhibitors (TKIs) are anticancer drugs with a lesser toxicity than classical chemotherapeutic agents but still with a narrow therapeutic window. While hepatotoxicity is known for most TKIs, underlying mechanisms remain mostly unclear. We therefore aimed at investigating mechanisms of...

Full description

Bibliographic Details
Main Authors: Franziska Paech, Jamal Bouitbir, Stephan Krähenbühl
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
tyrosine kinase inhibitor
hepatotoxicity
mitochondrial toxicity
glycolysis
ROS
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00367/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00367/full

Similar Items