Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model

Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model

Insertional leukemogenesis represents the major risk factor of hematopoietic stem cell (HSC) based gene therapy utilizing integrating viral vectors. To develop a pre-clinical model for the evaluation of vector-related genotoxicity directly in the relevant human target cells, cord blood CD34+ HSCs we...

Full description

Bibliographic Details
Main Authors: Reinhard Haemmerle, Ruhi Phaltane, Michael Rothe, Simon Schröder, Axel Schambach, Thomas Moritz, Ute Modlich
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
clonal dominance
insertional mutagenesis
murine xenotransplant model
retroviral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116303389

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116303389

Similar Items