Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

Photoreceptors are the most numerous and metabolically demanding cells in the retina. Their primary nutrient source is the choriocapillaris, and both the choriocapillaris and photoreceptors require trophic and functional support from retinal pigment epithelium (RPE) cells. Defects in RPE, photorecep...

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Bibliographic Details
Main Authors: Toshihide Kurihara, Peter D Westenskow, Marin L Gantner, Yoshihiko Usui, Andrew Schultz, Stephen Bravo, Edith Aguilar, Carli Wittgrove, Mollie SH Friedlander, Liliana P Paris, Emily Chew, Gary Siuzdak, Martin Friedlander
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
age-related macular degeneration
neurovascular crosstalk
hypoxia
Online Access:https://elifesciences.org/articles/14319

Internet

https://elifesciences.org/articles/14319

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