Attenuation of hyperlipidemia- and diabetes-induced early-stage apoptosis and late-stage renal dysfunction via administration of fibroblast growth factor-21 is associated with suppression of renal inflammation.

Attenuation of hyperlipidemia- and diabetes-induced early-stage apoptosis and late-stage renal dysfunction via administration of fibroblast growth factor-21 is associated with suppression of renal inflammation.

BACKGROUND: Lipotoxicity is a key feature of the pathogenesis of diabetic kidney disease, and is attributed to excessive lipid accumulation (hyperlipidemia). Increasing evidence suggests that fibroblast growth factor (FGF)21 has a crucial role in lipid metabolism under diabetic conditions. OBJECTIVE...

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Bibliographic Details
Main Authors: Chi Zhang, Minglong Shao, Hong Yang, Liangmiao Chen, Lechu Yu, Weitao Cong, Haishan Tian, Fangfang Zhang, Peng Cheng, Litai Jin, Yi Tan, Xiaokun Li, Lu Cai, Xuemian Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3857822?pdf=render

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http://europepmc.org/articles/PMC3857822?pdf=render

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