Nrf1D Is the First Candidate Secretory Transcription Factor in the Blood Plasma, Its Precursor Existing as a Unique Redox-Sensitive Transmembrane CNC-bZIP Protein in Hemopoietic and Somatic Tissues

Nrf1D Is the First Candidate Secretory Transcription Factor in the Blood Plasma, Its Precursor Existing as a Unique Redox-Sensitive Transmembrane CNC-bZIP Protein in Hemopoietic and Somatic Tissues

Among multiple distinct isoforms, Nrf1D is synthesized from a de novo translation of an alternatively-spliced transcript of Nrf1 mRNA, as accompanied by a naturally-occurring deletion of its stop codon-flanking 1466 nucleotides. This molecular event leads to the generation of a reading frameshift mu...

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Bibliographic Details
Main Authors: Jianxin Yuan, Hongxia Wang, Yuancai Xiang, Shaofan Hu, Shaojun Li, Meng Wang, Lu Qiu, Yiguo Zhang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
Nrf1
Nrf1D
secretory transcription factor
transmembrane
redox stress
alternative splicing
moving membrane-proteins
dynamic topobiology
unconventional protein secretion
Online Access:http://www.mdpi.com/1422-0067/19/10/2940

Internet

http://www.mdpi.com/1422-0067/19/10/2940

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