A hepatitis C virus infection model with time-varying drug effectiveness: solution and analysis.

Simple models of therapy for viral diseases such as hepatitis C virus (HCV) or human immunodeficiency virus assume that, once therapy is started, the drug has a constant effectiveness. More realistic models have assumed either that the drug effectiveness depends on the drug concentration or that the...

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Bibliographic Details
Main Authors: Jessica M Conway, Alan S Perelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-08-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4125050?pdf=render