The Combined Treatment with Chemotherapeutic Agents and the Dualsteric Muscarinic Agonist Iper-8-Naphthalimide Affects Drug Resistance in Glioblastoma Stem Cells

The Combined Treatment with Chemotherapeutic Agents and the Dualsteric Muscarinic Agonist Iper-8-Naphthalimide Affects Drug Resistance in Glioblastoma Stem Cells

Background: Glioblastoma multiforme (GBM) is characterized by heterogeneous cell populations. Among these, the Glioblastoma Stem Cells (GSCs) fraction shares some similarities with Neural Stem Cells. GSCs exhibit enhanced resistance to conventional chemotherapy drugs. Our previous studies demonstrat...

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Bibliographic Details
Main Authors: Claudia Guerriero, Carlo Matera, Donatella Del Bufalo, Marco De Amici, Luciano Conti, Clelia Dallanoce, Ada Maria Tata
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
M2 muscarinic receptor
glioblastoma
cancer stem cells
drug resistance
efflux pumps
chemotherapy
Online Access:https://www.mdpi.com/2073-4409/10/8/1877

Internet

https://www.mdpi.com/2073-4409/10/8/1877

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