Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains.

Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains.

Cell polarity plays a critical role in neuronal differentiation during development of the central nervous system (CNS). Recent studies have established the significance of atypical protein kinase C (aPKC) and its interacting partners, which include PAR-3, PAR-6 and Lgl, in regulating cell polarizati...

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Bibliographic Details
Main Authors: Tomoyuki Yamanaka, Asako Tosaki, Masaru Kurosawa, Kazunori Akimoto, Tomonori Hirose, Shigeo Ohno, Nobutaka Hattori, Nobuyuki Nukina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3877147?pdf=render

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http://europepmc.org/articles/PMC3877147?pdf=render

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