Mismatch repair deficiency is associated with specific morphologic features and frequent loss of ARID1A expression in ovarian clear cell carcinoma

Mismatch repair deficiency is associated with specific morphologic features and frequent loss of ARID1A expression in ovarian clear cell carcinoma

Abstract Background Ovarian clear cell carcinoma (OCCC) is the second subtype of ovarian epithelial carcinoma reported to be closely related to Lynch syndrome (LS). ARID1A mutation is an important pathogenetic mechanism in OCCC that leads to loss of ARID1A expression in approximately half of OCCCs....

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Bibliographic Details
Main Authors: Huijuan Ge, Yaoxin Xiao, Guangqi Qin, Yanzi Gu, Xu Cai, Wenhua Jiang, Xiaoyu Tu, Wentao Yang, Rui Bi
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Diagnostic Pathology
Subjects:
Ovarian clear cell carcinoma
Deficient MMR (dMMR)
Diffuse intratumoral stromal inflammation
MSH2/MSH6
ARID1A
Online Access:https://doi.org/10.1186/s13000-021-01071-w

Internet

https://doi.org/10.1186/s13000-021-01071-w

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