α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding

α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding

Invariant natural killer T (iNKT) cells, which are activated by T cell receptor (TCR)-dependent recognition of lipid-based antigens presented by the CD1d molecule, have been shown to participate in the pathogenesis of many diseases, including asthma and liver injury. Previous studies have shown the...

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Bibliographic Details
Main Authors: Alan Chuan-Ying Lai, Po-Yu Chi, Christina Li-Ping Thio, Yun-Chiann Han, Hsien-Neng Kao, Hsiao-Wu Hsieh, Jacquelyn Gervay-Hague, Ya-Jen Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Chemistry
Subjects:
NKT cell
glycolipid
CD1d
asthma
liver injury
ConA
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00811/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00811/full

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