The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid.

The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid.

CD4(+) T-cells from gut-associated lymphoid tissues (GALT) are major targets for HIV-1 infection. Recruitment of excess effector CD8(+) T-cells in the proximity of target cells is critical for the control of viral replication. Here, we investigated the colocalization potential of HIV-specific CD8(+)...

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Bibliographic Details
Main Authors: Vanessa Sue Wacleche, Nicolas Chomont, Annie Gosselin, Patricia Monteiro, Mathieu Goupil, Hassen Kared, Cécile Tremblay, Nicole Bernard, Mohamed-Rachid Boulassel, Jean-Pierre Routy, Petronela Ancuta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3314661?pdf=render

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