The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid.
CD4(+) T-cells from gut-associated lymphoid tissues (GALT) are major targets for HIV-1 infection. Recruitment of excess effector CD8(+) T-cells in the proximity of target cells is critical for the control of viral replication. Here, we investigated the colocalization potential of HIV-specific CD8(+)...
Main Authors: | Vanessa Sue Wacleche, Nicolas Chomont, Annie Gosselin, Patricia Monteiro, Mathieu Goupil, Hassen Kared, Cécile Tremblay, Nicole Bernard, Mohamed-Rachid Boulassel, Jean-Pierre Routy, Petronela Ancuta |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3314661?pdf=render |
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