Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians

Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians

Abstract Background The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear. Methods We used data from Biobank Japan (n = 70,657–128,305) and developed novel East Asian-specific genome-wide polyge...

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Bibliographic Details
Main Authors: Claudia H. T. Tam, Cadmon K. P. Lim, Andrea O. Y. Luk, Alex C. W. Ng, Heung-man Lee, Guozhi Jiang, Eric S. H. Lau, Baoqi Fan, Raymond Wan, Alice P. S. Kong, Wing-hung Tam, Risa Ozaki, Elaine Y. K. Chow, Ka-fai Lee, Shing-chung Siu, Grace Hui, Chiu-chi Tsang, Kam-piu Lau, Jenny Y. Y. Leung, Man-wo Tsang, Grace Kam, Ip-tim Lau, June K. Y. Li, Vincent T. F. Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk-lun Cheng, Chun-chung Chow, Miao Hu, Weichuan Yu, Stephen K. W. Tsui, Yu Huang, Huiyao Lan, Cheuk-chun Szeto, Nelson L. S. Tang, Maggie C. Y. Ng, Wing-yee So, Brian Tomlinson, Juliana C. N. Chan, Ronald C. W. Ma, The Hong Kong Diabetes Register TRS Study Group, The Hong Kong Diabetes Biobank Study Group
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Genome Medicine
Subjects:
Polygenic risk scores
Lipid traits
Subclinical atherosclerosis
Diabetes cardiovascular complications
East Asians
Online Access:https://doi.org/10.1186/s13073-021-00831-z

Internet

https://doi.org/10.1186/s13073-021-00831-z

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