An attenuated herpes simplex virus type 1 (HSV1) encoding the HIV-1 Tat protein protects mice from a deadly mucosal HSV1 challenge.

An attenuated herpes simplex virus type 1 (HSV1) encoding the HIV-1 Tat protein protects mice from a deadly mucosal HSV1 challenge.

Herpes simplex virus types 1 and 2 (HSV1 and HSV2) are common infectious agents in both industrialized and developing countries. They cause recurrent asymptomatic and/or symptomatic infections, and life-threatening diseases and death in newborns and immunocompromised patients. Current treatment for...

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Bibliographic Details
Main Authors: Mariaconcetta Sicurella, Francesco Nicoli, Eleonora Gallerani, Ilaria Volpi, Elena Berto, Valentina Finessi, Federica Destro, Roberto Manservigi, Aurelio Cafaro, Barbara Ensoli, Antonella Caputo, Riccardo Gavioli, Peggy C Marconi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4102458?pdf=render

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http://europepmc.org/articles/PMC4102458?pdf=render

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