Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
It is unclear whether fallopian tube epithelium or ovarian surface epithelium is the cell-of-origin of high grade serous ovarian carcinoma (HGSOC). Here the authors report a dualistic origin for HGSOC using genetically engineered mouse models and observe differential chemotherapy sensitivity dependi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13116-2 |